St. Gregory of Nyssa (c 335 – after 394) was a Christian bishop and saint. He was a younger brother of Basil the Great and a good friend of Gregory of Nazianzus. His significance has long been recognized in the Eastern Orthodox, Oriental Orthodox, Eastern Catholic and Roman Catholic branches of Christianity. Some historians identify Theosebia the deaconess as his wife, others hold that she, like Macrina the Younger, was actually a sister of Gregory and Basil. Gregory along with his brother Basil of Caesarea and Gregory of Nazianzus are known as the Cappadocian Fathers. They attempted to establish Christian philosophy as superior to Greek philosophy.

On the Making of Man was intended to supplement and complete the Hexaëmeron of St. Basil, and it presupposes an acquaintance with that treatise. The narrative of the creation of the world is not discussed in detail: it is referred to, but chiefly in order to insist on the idea that the world was prepared to be the sphere of man's sovereignty. On the other hand, Gregory shows that man was made with circumspection, fitted by nature for rule over the other creatures, made in the likeness of God in respect of various moral attributes, and in the possession of reason, while differing from the Divine nature in that the human mind receives its information by means of the senses and is dependent on them for its perception of external things. The body is fitted to be the instrument of the mind, adapted to the use of a reasonable being: and it is by the possession of the rational soul, as well as of the natural or vegetative and the sensible soul, that man differs from the lower animals.